Mysteries of magnesium homeostasis.

نویسنده

E Murphy

چکیده

In this issue of Circulation Research, Romani and colleagues1 report that insulin stimulates uptake of ionized magnesium (Mg) into heart. This study is the latest in a series by Romani, Scarpa, and colleagues regarding hormoneregulated Mg fluxes in heart and liver (References 1 and 2 and references therein). Over the past several decades, we have begun to uncover the mysteries of how cytosolic ionized calcium (Ca) is regulated and how it regulates cell function. However, the more abundant divalent cation Mg still holds many secrets for us to unravel. Ca signaling is facilitated by the large Ca gradients (up to 10 000-fold) across the plasma and sarcoplasmic reticulum (SR) membranes. In contrast, only small gradients of Mg (generally a factor of 2 or less) are reported across the plasma or intracellular membranes.3–5 In contrast to Ca signaling, agonists do not cause large (order of magnitude) alterations in cytosolic Mg. Even upon hormonal stimulation, of heart and liver, which results in a 10% to 15% change in total cell magnesium, there is little or no change in cytosolic Mg. This lack of change in cytosolic Mg has led many investigators to question whether Mg is involved in hormone signaling.

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